Dr. J.M. Weiss
- Telephone:+31 20 59 86198
- Room nr:a-660
- E-mail:jana.weiss@vu.nl
- Unit:faculteit der aard- en levenswetenschappen (dep. chemistry and biology)
- Position:Senior Researcher
Summary
Jana finished her Ph.D. in environmental chemistry in Stockholm 2006, mainly focusing on analytical skills of organic environmental pollutants in several matrixes. During the Ph.D. studies she gained solid knowledge in quality control and statistical evaluation. Since then she has expanded her expertise by including the field of toxicology in the work performed during the first post doc at the IVM (2007-2009). The work performed there was implementing the Effect-Directed Analysis (EDA) approach which combines fractionation techniques and bioassays to guide the identification of key toxicants.
She also worked for the Joint Research Centre in Ispra, Italy for 2.5 years where she gained insight and experience to work for the European Commission. She was there involved in a project supporting the Stockholm Convention to facilitate the Global Monitoring of priority pollutants.
Now she is back at IVM, this time as project leader and she will participate in several European projects, e.g. PERFOOD and PHARMAS.
Expertise
• Environmental chemistry
• Analytical chemistry
• Gas Chromatography/mass spectrometry
• Method development for organic contaminants
• Effect-directed analysis (EDA)
• Identification strategies
• Polychlorinated biphenyls (PCBs), and their metabolites
• Brominated flame retardants (BFRs)
• Per- and polyfluoroalkyl substances (PFAS)
• Emerging contaminants
Academic training
| 2006 | Doctor of Philosophy at the Department of Environmental Chemistry, Stockholm University, Sweden. Supervised by Åke Bergman. |
| 2001 | Bachelor at the Department of Environmental Chemistry, Stockholm University, Sweden and work performed at Ergo Forschungsgesellschaft, Hamburg, Germany. Supervised by Åke Bergman and Olaf Päpke. |
Professional employment history
| 2011 to present | Employed as project manager to contribute to the implementation of existing national and international projects and to acquire competitive projects to the institute. Projects are e.g. PERFOOD (investigating the presence and behaviour of per- and polyfluoroalkyl substances in our surrounding environment and food), PHARMAS (performing a human health risk assessment of antibiotics and anti-cancer drugs found in the environment) |
| 2009-2011 | As an experienced researcher the main task was to implement an ongoing project, supporting the Global Monitoring Network Plan under the Stockholm Convention to facilitate the monitoring of POPs and their world-wide distribution. Except working with well known analytical tools such as GC/MS and other laboratory techniques (GPC, SPE, LC etc), the dataset produced will be geographically evaluated to calibrate the theoretical model. |
| 2007-2009 | Employed as an analytical/environmental chemist to support the Water Framework Directive with the aim to identify chemical key-toxicants in European water systems. This was performed by the Effect-Directed Analysis (EDA) approach, combining chemistry and toxicology to isolate effect-causing compounds for identification. I broadened my knowledge within the field of toxicology and worked with the performance of bioassays and interpretation of the results (e.g. TTR-binding, AR/ER-calux, UmuC etc.), which guides the fractionation steps to simplify the complex mixture in an environmental sample. Much focus was put on the identification of the effect-causing compounds, using complementary analytical techniques (e.g. GC/MS, LC/MS, LTQ-Orbitrap) |
Selected publications
Meijer, L., Martijn, A., Melessen, J., Brouwer, A., Weiss, J., Jong, F.H. de & Sauer, P.J. (2012). Influence of prenatel organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length. Human Reproduction. In Press.
Weiss, J.M., Eszter, S., Stroomberg, G., Boer, R.de, Boer, J. de, Linden, S. van der, Leonards, P.E.G. & Lamoree, M.H. (2011). Integrated identification strategy for unknown pollutants on an LTQ-Orbitrap: androgen disrupting compounds identified using effect-directed analysis. Analytical and Bioanalytical Chemistry, 400, 3141-3149.
Lübcke-von Varel, U., Machala, M., Ciganek, M., Neca, J., Pencikova, K., Vykopalova, L., Vondracek, J., Löffler, I., Streck, G., Reifferscheid, G., Flückiger-Isler, S., Weiss, J.M., Lamoree, M. & Brack, W. (2011). Polar compounds dominate in vitro effects of sediment extracts. Environmental Science & Technology, 45, 2384-2390.
Simon, E., Leonards, P.E.G., Balaam, J., Roberts, P., Weiss, J.M., Cenijn, P., Hamers, T., Lamoree, M. & Boer, J. de (2010). Lipid removal from biota extracts for application in Effect Directed Analysis using thyroid hormone inhibition and (anti-) androgenic activity biological assays. Environmental Science & Technology, 44, 8322-8329
Weiss, J.M., Hamers, T., Thomas, K.V., Linden, S. van der, Leonards, P.E.G. Lamoree, M.H. (2009). Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis. Analytical and Bioanalytical Chemistry, 394, 1385-1397
Weiss, J.M., Andersson, P.L., Lamoree, M.H., Leonards, P.E.G., van Leeuwen, S.P.J. & Hamers, T. (2009). Competitive binding of perfluorinated compounds to the thyroid hormone transport protein transthyretin. Toxicological Sciences, 109(2), 206-216.
Meijer, L., Weiss, J., Velzen, M. van, Brouwer, A., Bergman, Å. & Sauer, P. (2008). Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environmental Science & Technology, 42, 3428-33.
Weiss, J., Wallin, E., Axmon, A., Jönsson, B.A.G., Åkesson, H., Athanassiadis, I., Janak, K., Hagmar, L. & Bergman, Å. (2006). Analysis of PCB and its metabolites, PBDE and HBCDD in serum from an elderly population of Swedish fishermen and fishermen’s wives and association to bone fragility. Environmental Science & Technology, 40, 6282-6289.
Weiss, J., Päpke, O. & Bergman, Å. (2005). PCDDs/PCDFs and related contaminants in butter samples originating from 37 countries world-wide. Ambio, 34 (8), 589-597.
Weiss J., Päpke O., Bignert A., Jensen S., Greyerz E., Agostoni C., Besana R., Riva E., Giovannini M. & Zetterström R. (2003). Concentrations of dioxins and other organochlorines (PCBs, DDTs, HCHs) in human milk from Seveso, Milan and a Lombardian rural area in Italy: a study performed 25 years after the heavy dioxin exposure in Seveso. Acta Paediatr, 92, 467-472.
Link to full publication list at IVM since 2005
Books
Umbuzeiro, G., Machala, M. & Weiss, J. (2011). Diagnostic tools for effect-directed analysis of mutagens, AhR agonists, and endocrine disruptors. In Brack, W. (Ed.) Effect-directed analysis of complex environmental contamination. Handbook of Environmental Chemistry, 15, 69-82
Ancillary activities
